Hlavní ocenění: Best of Show: Assassin's Creed - Ubisoft, PlayStation 3
Best Trailer: Metal Gear Solid 4: Guns of the Patriots - Konami, PlayStation 3
Most Innovative: WarioWare: Smooth Moves - Nintendo, Wii
Best Graphics: Crysis - Electronic Arts, PC
Best Hardware: Xbox 360
Best User Submitted E3 Video: "Wii60 Rainbow 6 Trailer" - TXB Raptor
Ocenění podle žánru:
Best Shooter: Crysis - Electronic Arts, PC
Best Action/Adventure: The Legend of Zelda: Twilight Princess - Nintendo, Wii
Best Puzzle: Loco Roco - SCEA, Sony PSP
Best Strategy: Supreme Commander - THQ, PC
Best Role-Playing: Mass Effect - Microsoft Game Studios, Xbox 360
Best Sports: Wii Sports - Nintendo, Wii
Best Online: Tabula Rasa - NCSoft, PC
Best Racing: Test Drive Unlimited - Atari, Xbox 360
Best Fighting: Virtua Fighter 5 - Sega, PlayStation 3
Best Simulation: Guitar Hero II - RedOctane, PlayStation 2
Ocenění podle platformy:
Best Xbox 360: Gears of War - Microsoft Game Studios
Best PlayStation 3: Resistance: Fall of Man - SCEA
Best Nintendo Wii: The Legend of Zelda: Twilight Princess
Best Nintendo DS: The Legend of Zelda: Phantom Hourglass
Best Sony PSP: Tekken: Dark Resurrection - Namco Bandai
Best PC: Crysis - Electronic Arts